The sweet taste of success: Fructose for recovery in multi-stage races

Maintaining carbohydrate availability is a key challenge in multi-stage races

A major challenge in multi-stage races such as cycling’s Grand Tours, and the Marathon des Sables, is maintaining adequate carbohydrate availability. This is because we rapidly deplete carbohydrate stores during exercise, and we have a limited carbohydrate storage capacity. Furthermore, when carbohydrate stores a low, we have difficulty maintaining race-pace intensities of exercise. The storage form of carbohydrates in humans is glycogen, which is mainly found in muscle and the liver. The maximum amount of glycogen that an athlete can store is thought to be less than 3500 kcal of energy. This is not enough to support even one full day of racing, and even if athletes are consuming carbohydrates during exercise, they will almost always end up with low glycogen stores at the end of each stage. Therefore, rapidly replenishing these glycogen stores before beginning the next stage is a key nutritional consideration.

Muscle glycogen recovery is mostly dependent of the dose of carbohydrate ingested

Sports nutrition guidelines for recovery from exercise typically state that for rapid refuelling, athletes should aim to consume 1.0-1.2 grams of carbohydrate per kilogram body mass per hour for the first four hours following exercise(1). This is based on the substantial evidence that this rate of carbohydrate ingestion maximises muscle glycogen repletion rates. In terms of the types of carbohydrate to consume, this seems to be less important, as muscle glycogen repletion seems to be similar whether the source of carbohydrates are glucose-based, or glucose-fructose mixtures(2). However, much of the prior work on glycogen repletion has paid little attention to the effects of post-exercise nutrition on liver glycogen recovery. Liver glycogen availability may also be important for the capacity to perform prolonged exercise, and so it is likely to be important to understand the effects of nutrition on both liver and muscle glycogen stores.

Liver glycogen recovery is accelerated by fructose-containing carbohydrates

Compared to muscle glycogen, liver glycogen metabolism seems to be more sensitive to the type of carbohydrates that are ingested. For example, the co-ingestion of fructose (and galactose) with glucose-based carbohydrates potently increases the rate of liver, but not muscle glycogen repletion post-exercise(3; 4). The increased recovery of liver glycogen stores with fructose-glucose co-ingestion is typically double the rate of that seen with glucose alone, even when the total amount of carbohydrate is identical. Whilst these findings were promising, the next logical question to ask, is whether this potential advantage to increasing liver glycogen availability translates into a benefit to endurance performance.

Fructose-glucose mixtures during recovery improve subsequent exercise capacity

In a recent study, a group of runners performed two bouts of exhaustive running separated by 4 hours. During the 4-hour recovery period, the runners were provided with carbohydrate drinks containing either glucose-based carbohydrates, or glucose-fructose mixtures. After ingestion of the glucose-fructose mixtures, the athletes were able to run for ~30% longer, compared to the ingestion of equivalent amounts of glucose-based carbohydrates alone(5). This was an exciting finding, suggesting that the type of carbohydrate ingested during recovery from exercise could have an important effect of subsequent exercise capacity. However, it was still unknown whether this is relevant to multi-stage races, as most of these events have recovery durations longer than 4 hours, and include an overnight fast during sleep. This could have important implications for this as a nutritional strategy, as liver glycogen stores are used overnight to supply the brain and other tissues with glucose(6). Therefore, any potential benefit of fructose co-ingestion to liver glycogen stores could be lost overnight. A more recent study addressed this, by asking cyclists to perform exhaustive exercise and then to consume either fructose-glucose mixtures, or glucose-based carbohydrates alone, for 4 hours following exercise(7). Subsequent endurance capacity was then assessed after 15 hours of recovery, after an overnight fast and a low-carbohydrate breakfast. Remarkably, endurance capacity was improved by ~20%, suggesting that fructose-containing carbohydrates in the recovery diet of athletes may improve their capacity to perform exercise the following day.

Next steps

Whilst recent evidence suggests fructose co-ingestion may accelerate recovery in these specific conditions, further work is needed to establish the effectiveness of fructose co-ingestion on endurance recovery in elite athletes competing in true events. Differences in fitness levels and the patterns of food intake mean that we cannot yet be certain that there is a benefit of fructose co-ingestion for recovery in multi-stage events. For example, the large carbohydrate-rich breakfasts that riders have before stages could make the prior choice of carbohydrates on the evening before less relevant.


Maximising the repletion of carbohydrate stores post-exercise is a key factor in the recovery during multi-stage races. Whilst the recovery of muscle glycogen stores seems to be mainly dictated by the amount of carbohydrate ingested, rather than the type of carbohydrate, liver glycogen stores seem to be strongly influenced by the type of carbohydrate. Fructose-containing carbohydrates potently stimulate liver glycogen resynthesis, and can also improve the recovery of exercise capacity in both running and cycling, over timeframes that are relevant to many multi-stage races.

Athletes wishing to optimise post-exercise carbohydrate availability could consider aiming for 1.0-1.2 grams of fructose-containing carbohydrates per kilogram body mass per hour for the first four hours of recovery.


1.Thomas DT, Erdman KA, Burke LM (2016) American College of Sports Medicine Joint Position Statement. Nutrition and Athletic Performance. Med Sci Sports Exerc48, 543-568.

2.Wallis GA, Hulston CJ, Mann CHet al.(2008) Postexercise muscle glycogen synthesis with combined glucose and fructose ingestion. Med Sci Sports Exerc40, 1789-1794.

3.Décombaz J, Jentjens R, Ith Met al.(2011) Fructose and galactose enhance postexercise human liver glycogen synthesis. Med Sci Sports Exerc43, 1964-1971.

4.Fuchs CJ, Gonzalez JT, Beelen Met al.(2016) Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion compared with glucose ingestion in trained athletes. J Appl Physiol (1985)120, 1328-1334.

5.Maunder E, Podlogar T, Wallis GA (2018) Postexercise Fructose-Maltodextrin Ingestion Enhances Subsequent Endurance Capacity. Med Sci Sports Exerc50, 1039-1045.

6.Gonzalez JT, Fuchs CJ, Betts JAet al.(2016) Liver glycogen metabolism during and after prolonged endurance-type exercise. Am J Physiol Endocrinol Metab311, E543-553.

7.Gray EA, Green TA, Betts JAet al.(2019) Post-exercise glucose-fructose co-ingestion augments cycling capacity during short-term and overnight recovery from exhaustive exercise, compared to isocaloric glucose. Int J Sport Nutr Exerc Metab.DOI: 10.1123/ijsnem.2019-0211.

#liverglycogen #muscleglycogen #recovery #glycogen #exercise #endurance


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